Rejuran Treatment Process:
What Happens Step by Step

Before Treatment:
Consultation and Planning

The process starts with a consultation where a practitioner reviews your skin, discusses what you’re hoping to address, and confirms there’s no reason to delay treatment, such as an active infection or pregnancy. This is also when session count and spacing get planned, since a course is usually mapped out in advance rather than decided session by session. For the broader picture of what the treatment is meant to achieve, see our Rejuran Healer overview.

During the Session:
What the Appointment Involves

Numbing cream is applied and given time to take effect, typically 20 to 30 minutes, before the injections begin. The practitioner then works across the treatment area in a systematic pattern, and the injections usually take 20 to 40 minutes depending on the area size. Add the numbing time and a few minutes for cleansing and a soothing mask, and the visit comes to about an hour or a little more.

After Treatment:
Aftercare and Follow-Up

Mild redness, slight swelling and small raised bumps at the injection points are common for the first day or two, and gentle skincare with sun protection supports recovery during this window. Bruising does not happen to everyone, but when it does it can take up to about a week to fade, which matters if you have a flight or an event soon after. A first course is usually three to four sessions spaced two to four weeks apart, giving the skin time to respond before the next round.

This page covers the procedure itself. What the treatment can and cannot be expected to do is covered in our Rejuran benefits and effectiveness guide, and the fuller list of reactions is in Rejuran side effects.

For what determines how much this costs, our Rejuran cost guide covers the main factors, and if you’re researching this from outside Korea, how a Korean clinic consultation typically proceeds explains the coordination side.

How Published Protocols
Compare to What Clinics Do

If you want a sense of whether the plan you are offered is ordinary, the clinical literature gives a reference point. A systematic review of nine polynucleotide studies (published online in December 2024, in the 2025 volume of the Journal of Cosmetic Dermatology) describes protocols that are fairly consistent with each other.

Injections were given as serial punctures spaced roughly a centimetre apart rather than as a few larger deposits, using fine needles between 30G and 34G. Total dose ranged from 0.5 mL to 4 mL depending on how large the treated area was. Sessions were most commonly spaced two to four weeks apart, and follow-up in the studies ran from about three to six months.

Those numbers are useful as a sanity check rather than a rule. A plan that spaces sessions a week apart, or that uses a markedly larger volume for a small area, is not necessarily wrong, but it is a reasonable thing to ask about. The reverse is also true: if a clinic quotes a three-session course at three-week intervals, that sits squarely inside what the published studies did.

Where the Discomfort
Sits in the Process

The step most people ask about is the injections themselves, and there is survey data on how much of an obstacle that actually is in practice.

A 2026 nationwide survey of 501 dermatologists in the Korean Society for Anti-Aging Dermatology looked at polynucleotide injections used to prevent and treat scars, which is a narrower use than general skin rejuvenation. Among the dermatologists who did not use them for scars, injection discomfort was named by roughly a quarter, behind product cost at about two-thirds and limited awareness of the treatment’s role in scar care at about half. So discomfort is a recognised feature of the procedure, not something clinics can pretend away. It still ranked below cost and awareness as a reason not to use the treatment.

That ordering is worth carrying into the appointment. Discomfort is managed rather than eliminated, and the levers are the ones already built into the process described above: topical anaesthetic and the time it is given to work, injection depth and technique, and how much is done in a single sitting. For scar work, the same survey found intradermal injection across three sessions to be the most common approach, which spreads the work rather than concentrating it.

If the prospect is what is holding you back, it is better raised at consultation than on the day. A practitioner who knows in advance can adjust the numbing protocol; one who finds out mid-session has fewer options.

Frequently Asked
Questions

How long before I can wear makeup after a session?

Most practitioners recommend waiting at least a few hours, and some suggest a full day, to reduce the risk of irritation at injection points.

Can I exercise the same day as treatment?

Light activity is usually fine, but strenuous exercise is often discouraged for the rest of the day since increased blood flow can worsen temporary swelling.

What should I avoid before my appointment?

Avoiding blood thinners like aspirin for a few days beforehand, when medically appropriate, can reduce bruising risk; discuss any medications with your practitioner first.

How soon can I book my next session?

This depends on your specific plan, but sessions are typically spaced two to four weeks apart to allow the skin to respond between treatments.

Is there a consultation fee separate from treatment?

This varies by clinic, so it’s worth confirming pricing structure, including whether the consultation itself carries a separate charge, before booking.