How Often Should You Get Rejuran
Once Your Initial Course Is Done

Why an Initial Course
Isn’t a One-Time Fix

The collagen-building effects Rejuran encourages don’t last indefinitely once you stop treatment, since normal aging and environmental factors continue afterward. This is true of most regenerative treatments, not a specific weakness of Rejuran; maintenance is simply part of how the approach, covered in our Rejuran Healer overview, is designed to work long-term rather than a sign the initial course failed.

What Determines
Your Maintenance Interval

A few factors influence how often maintenance actually makes sense for a given person.

What a Maintenance
Session Typically Looks Like

Maintenance sessions are generally lighter than the initial course, often just one visit rather than a repeated series, since the goal is sustaining existing results rather than building from scratch again. A practitioner can assess how your skin has held since your last session and recommend timing based on that, rather than following a fixed calendar for everyone.

For what results look like at each stage, see our before and after guide, and for the fuller picture of a treatment course, our treatment process guide covers what to expect.

Two Clocks Running
at Different Speeds

Scheduling questions get confusing because two separate processes are running after a session, and they do not finish together.

The first is mechanical recovery from the injections themselves: puncture marks that settle within a day, small firm bumps that flatten over one to three days, and a bruise, if one forms, which usually takes about a week to fade and occasionally longer. The second is the biological response: fibroblasts increasing collagen output. A 2026 narrative review describes results becoming apparent at around four to eight weeks and improving over three to six months. Our side effects guide covers the first clock in more detail.

Session intervals are set by the second clock, not the first. That is why courses are typically spaced two to four weeks apart rather than as soon as the skin looks normal: the point is to stack the biological response, not to wait for the redness to go.

It also explains why a maintenance interval is longer than a course interval. During the initial course the aim is accumulation; afterwards it is holding a level that declines slowly. A clinic proposing monthly maintenance indefinitely is proposing something different from what the initial course was for, and that is a fair thing to ask about.

What Intervals
Published Studies Actually Used

Since maintenance intervals differ between clinics, it is worth knowing what intervals the published work used, if only as a reference range.

Three recent studies in the Journal of Cosmetic Dermatology give three different shapes. A 2025 multicentre lip study ran three injections three weeks apart, with assessment at weeks 0, 3, 6 and 9. A 2026 periorbital study gave two sessions three weeks apart, adding a third only for patients whose wrinkles were still moderate to severe, and measured outcomes at one, three and six months. A 2026 survey of 501 Korean dermatologists asked about polynucleotide use for scar prevention and management, and found three intradermal sessions the most common approach in that setting.

What those have in common is a short initial course of two to three sessions, with three-week spacing in both trials (the survey did not look at spacing). None of them was designed to answer the maintenance question at all. Follow-up in the periorbital study ran to six months, the longest window of the three, and its authors still called for controlled studies to refine protocols.

So the honest position is that the initial course has a rough consensus behind it and the maintenance interval does not. A clinic recommending a refresh at a particular month is applying experience to a question the literature has not settled, which is entirely legitimate. It is also a good reason to ask what they will be watching for to decide, rather than treating the interval as a fixed schedule.

Frequently Asked
Questions

Do I need to redo the full course every time?

No, maintenance is typically a single session rather than repeating the entire initial course, assuming the initial results were established well.

What happens if I skip maintenance for a long time?

Results gradually fade as normal aging continues. How much of the improvement is left after a long gap varies from person to person and has not been studied well, so a practitioner may suggest a short new course rather than a single top-up.

Can maintenance intervals get longer over time?

Some patients find their skin holds results longer after a few years of consistent maintenance, though this varies by individual and isn’t guaranteed.

Is a maintenance session cheaper than the initial course?

Typically, since it’s usually a single session rather than a multi-session series, though pricing still varies by clinic and treatment area.

How do I know when it’s time for a maintenance session?

Noticing results gradually fading, or simply reaching the interval your practitioner recommended, are the usual signals; a check-in consultation can confirm timing.

How long do results last once the course is finished?

Clinics commonly describe results lasting several months after a completed course, with maintenance used to hold the level rather than to build further. No long-term trial has pinned the figure down, and it depends on age, baseline skin condition and sun exposure, which is why maintenance timing is decided person by person.

How many sessions are in a standard course?

Three to four sessions spaced two to four weeks apart is the plan most studies describe, according to a 2026 narrative review, and providers adjust it to the skin in front of them. Results are described as visible from about four to eight weeks and improving over three to six months, so the full effect arrives after the course rather than at its last session.